Measurement of Radiotracer Concentration in Brain Gray Matter Using Positron Emission Tomography: MRI-Based Correction for Partial Volume Effects
نویسندگان
چکیده
منابع مشابه
Measurement of radiotracer concentration in brain gray matter using positron emission tomography: MRI-based correction for partial volume effects.
Accuracy in in vivo quantitation of brain function with positron emission tomography (PET) has often been limited by partial volume effects. This limitation becomes prominent in studies of aging and degenerative brain diseases where partial volume effects vary with different degrees of atrophy. The present study describes how the actual gray matter (GM) tracer concentration can be estimated usi...
متن کاملPositron emission tomography partial volume correction: estimation and algorithms.
Partial volume effects in positron emission tomography (PET) lead to quantitative under- and over-estimations of the regional concentrations of radioactivity in reconstructed images and corresponding errors in derived functional or parametric images. The limited resolution of PET leads to "tissue-fraction" effects, reflecting underlying tissue heterogeneity, and "spillover" effects between regi...
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Quantitative accuracy of positron emission tomography (PET) is decreased by the partial volume effect (PVE). The PVE correction (PVC) methods proposed by Alfano et al., Rousset et al., Müller-Gärtner et al. and Meltzer et al. were evaluated in the present study to obtain guidelines for selecting among them. For accuracy evaluation, the Hoffman brain phantom was scanned with three PETs of differ...
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We describe a generic methodology to correct 3-D partial volume effects in clinical emission scans. It is based on prior knowledge of tracer biodistribution and tomographic imaging characteristics. We derive this information from registered and segmented MR/CT data. Two fast numerical algorithms are then used to estimate structure-specific recovery coefficients and activity spillover contributi...
متن کاملEvaluation of a 3D local multiresolution algorithm for the correction of partial volume effects in positron emission tomography.
PURPOSE Partial volume effects (PVEs) are consequences of the limited spatial resolution in emission tomography leading to underestimation of uptake in tissues of size similar to the point spread function (PSF) of the scanner as well as activity spillover between adjacent structures. Among PVE correction methodologies, a voxel-wise mutual multiresolution analysis (MMA) was recently introduced. ...
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ژورنال
عنوان ژورنال: Journal of Cerebral Blood Flow & Metabolism
سال: 1992
ISSN: 0271-678X,1559-7016
DOI: 10.1038/jcbfm.1992.81